Function of adrenal cortex3/26/2023 ![]() ![]() ![]() We show that adrenal glands of mice fed a HFD release more corticosterone and aldosterone, resulting in higher plasma levels. We then assessed various aspects of adrenal gland morphology and function, as well as basal plasma concentrations of steroid hormones and ACTH. We fed animals either a high-fat diet (HFD) or a normal diet (60% kcal from fat or 10% kcal from fat, respectively) for 18 weeks. Here, we investigated how diet-induced obesity affects the morphology and function of the mouse adrenal cortex. The mechanisms underlying obesity-related alterations in adrenal steroids are still not well understood. Elevated levels of these hormones induce insulin resistance and cause cardiovascular diseases. Obesity and diabetes are intimately linked with altered levels of adrenal steroids. Obesity is a major risk factor for the development of type 2 diabetes and other debilitating diseases. ![]()
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